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《农业科学与工程前沿(英文)》 2022年 第9卷 第1期 页码 120-132 doi: 10.15302/J-FASE-2021410
Naturally-occurring environmental microorganisms may provide ‘green’ and effective biocontrol tools for disease management in agricultural crops. Due to the constant threat of resistant pathogens there is a pressing and continual need to search for new biocontrol tools. This study investigated the production of new analogs of WAP-8294A compounds by the biocontrol agent Lysobacter enzymogenes OH11 through biosynthetic engineering. WAP-8294As are a family of natural cyclic lipodepsipeptides with potent activity against Gram-positive bacteria. A series of genetic manipulations was therefore conducted on the accessory genes in the WAP biosynthetic gene cluster. The resulting strains containing a single-point mutation in ORF4, which was predicted to encode a 2-ketoglutarate dependent dioxygenase, produced deoxy-WAP-8294As. This result provides evidence for the function of ORF4 in catalyzing β-hydroxylation of the D-asparagine residue in WAP-8294As. In addition, six new analogs of WAP-8294As were identified by UHPLC-HR-MS/MS. This is the first attempt to produce new WAP-8294As in Lysobacter and shows that the spectrum of the biocontrol compounds may be expanded through the manipulation of biosynthetic genes.
关键词: biocontrol / biosynthesis / Lysobacter / natural products / WAP-8294A
《农业科学与工程前沿(英文)》 2023年 第10卷 第2期 页码 306-332 doi: 10.15302/J-FASE-2023488
● Using visual analysis to predict the trend of natural product pest resistance.
关键词: anti-pest activity crop protection insect pest natural product visual analysis
Compressive behavior and microstructure of concrete mixed with natural seawater and sea sand
《结构与土木工程前沿(英文)》 2021年 第15卷 第6期 页码 1347-1357 doi: 10.1007/s11709-021-0780-2
关键词: seawater and sea sand concrete compressive strength strain field microstructure hydration products
《农业科学与工程前沿(英文)》 2021年 第8卷 第2期
Ascorbic acid (AsA, vitamin C) is involved in the regulation of many aspects of plant growth and development. It is an essential micronutrient for humans and can prevent scurvy, maintain the health of gums and blood vessels, reduce the level of plasma cholesterol and enhance the immune systen. Apple cultivars Orin and Guanghui were crossed to obtain a group of hybrid offspring with and without red flesh in the course of assessing apple germplasm resources. Unexpectedly, the red-flesh apples had higher AsA contents than other apples. Further studies showed that the anthocyanin biosynthetic regulator MdMYB1 directly activates the expression of dehydroascorbate reductase gene MdDHAR, thus promoting the activity of the DHAR enzyme and the accumulation of AsA. This finding reveals the mechanism leading to high AsA levels in red-flesh apples and suggests a new idea to cultivate red-flesh apples with high AsA contents and produce AsA efficiently and without pollution.
Development of a dual temperature control system for isoprene biosynthesis in
《化学科学与工程前沿(英文)》 2022年 第16卷 第7期 页码 1079-1089 doi: 10.1007/s11705-021-2088-0
关键词: transcriptional activator directed evolution dynamic control heat-shock isoprene
Jianping AN, Xiaofei WANG, Chunxiang YOU, Yujin HAO
《农业科学与工程前沿(英文)》 页码 231-235 doi: 10.15302/J-FASE-2020367
Jiuxiao Hao, Xiujin Wang, Hui Wang
《环境科学与工程前沿(英文)》 2017年 第11卷 第1期 doi: 10.1007/s11783-017-0896-8
关键词: Polyhydroxyalkanoates (PHAs) Valerate Mixed culture 3-hydroxyvalerate (3HV) Propionate
Kandasamy SARAVANAKUMAR, Zhixiang LU, Hai XIA, Meng WANG, Jianan SUN, Shaoqing WANG, Qiang-qiang WANG, Yaqian LI, Jie CHEN
《农业科学与工程前沿(英文)》 2018年 第5卷 第2期 页码 271-279 doi: 10.15302/J-FASE-2018214
关键词: anthraquinone Botrytis cinerea harzianolide harzianopyridone molecular docking Trichoderma harzianum
《环境科学与工程前沿(英文)》 2023年 第17卷 第9期 doi: 10.1007/s11783-023-1716-y
● A systematic framework was developed to identify i-PPCPs for landfill leachate.
关键词: Landfill leachates PPCPs Indicator Screening criteria Source-specificity
Bacteriophages in water pollution control: Advantages and limitations
《环境科学与工程前沿(英文)》 2021年 第15卷 第5期 doi: 10.1007/s11783-020-1378-y
•Phages can be better indicators of enteric viruses than fecal indicator bacteria.
关键词: Phage Water pollution monitoring Harmful bacteria biocontrol Horizontal gene transfer Bacterial resistance
《环境科学与工程前沿(英文)》 2022年 第16卷 第12期 doi: 10.1007/s11783-022-1585-9
● The physicochemical and structural properties of DBC were characterized.
关键词: Dissolved black carbon (DBC) Chlorine Chloramine Disinfection by-products (DBPs) Disinfection by-products formation potential (DBPFP)
《环境科学与工程前沿(英文)》 2023年 第17卷 第8期 doi: 10.1007/s11783-023-1694-0
● Data quality assessment criteria for MP/NPs in food products were developed.
关键词: Microplastic Nanoplastic Food products Data quality Human health risk
Assembly of biosynthetic pathways in
Lidan Ye,Xiaomei Lv,Hongwei Yu
《化学科学与工程前沿(英文)》 2017年 第11卷 第1期 页码 126-132 doi: 10.1007/s11705-016-1597-8
关键词: pathway assembly toolbox reiterative recombination S. cerevisiae biosynthesis
Yong YU,Laosheng WU
《环境科学与工程前沿(英文)》 2015年 第9卷 第3期 页码 475-481 doi: 10.1007/s11783-014-0640-6
关键词: endocrine disrupting compounds (EDCs) pharmaceuticals and personal care products (PPCPs) fish bisphenol A (BPA) risk assessment
《环境科学与工程前沿(英文)》 2023年 第17卷 第7期 doi: 10.1007/s11783-023-1691-3
● A better risk assessment can combine the improved non-target analysis method.
关键词: Risk assessment frameworks Transformation products Emerging contaminants High-throughput toxicity screening Water treatment
标题 作者 时间 类型 操作
PRODUCTION OF NEW WAP-8294A CYCLODEPSIPEPTIDES BY THE BIOLOGICAL CONTROL AGENT LYSOBACTER ENZYMOGENES
期刊论文
QUANTITATIVE STUDY ON ANTI-PEST ACTIVITY OF NATURAL PRODUCTS BASED ON VISUALIZATION FRAMEWORK OF KNOWLEDGE
期刊论文
THE ANTHOCYANIN BIOSYNTHETIC REGULATOR MDMYB1 POSITIVELY REGULATES ASCORBIC ACID BIOSYNTHESIS IN APPLE
期刊论文
THE ANTHOCYANIN BIOSYNTHETIC REGULATOR MDMYB1 POSITIVELY REGULATES ASCORBIC ACID BIOSYNTHESIS IN APPLE
Jianping AN, Xiaofei WANG, Chunxiang YOU, Yujin HAO
期刊论文
Investigation of polyhydroxyalkanoates (PHAs) biosynthesis from mixed culture enriched by valerate-dominant
Jiuxiao Hao, Xiujin Wang, Hui Wang
期刊论文
Triggering the biocontrol of
Kandasamy SARAVANAKUMAR, Zhixiang LU, Hai XIA, Meng WANG, Jianan SUN, Shaoqing WANG, Qiang-qiang WANG, Yaqian LI, Jie CHEN
期刊论文
Screening of indicator pharmaceuticals and personal care products in landfill leachates: a case study
期刊论文
Characteristics of typical dissolved black carbons and their influence on the formation of disinfection by-products
期刊论文
Data quality assessment for studies investigating microplastics and nanoplastics in food products: Are
期刊论文
Determination and occurrence of endocrine disrupting compounds, pharmaceuticals and personal care products
Yong YU,Laosheng WU
期刊论文